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To manage the symptoms of CRPS, doctors use various medications.
Over-the-counter pain relievers such as aspirin, ibuprofen (Advil, Motrin IB, and other brands), and naproxen sodium (Aleve) can help reduce minor pain and inflammation. If these medications are ineffective, your doctor may recommend stronger options. Opioids might be considered and, when used sparingly, can assist with pain management.
Antidepressants and anticonvulsants. Neuropathic pain, resulting from nerve damage, can sometimes be treated with antidepressants like amitriptyline and anticonvulsants such as gabapentin (Gralise, Neurontin).
Steroids like prednisone may help reduce inflammation and improve the range of motion in the affected limb.
Medications to prevent bone loss. Your doctor may prescribe medications to stop or prevent bone loss, such as calcitonin (Miacalcin) and alendronate (Binosto, Fosamax).
Sympathetic nerve-blocking medications. Some patients may experience pain relief from injections of anesthetics that block pain fibers in the affected nerves.
Intravenous ketamine. Research suggests that small doses of intravenous ketamine, a potent anesthetic, can significantly reduce pain.
Blood pressure medications. Certain high blood pressure medications, such as clonidine, phenoxybenzamine (Dibenzyline), and prazosin (Minipress), may sometimes aid in pain management.
Thermal Treatment: Applying heat to areas of the skin that feel cold may help reduce swelling and discomfort.
Topical Painkillers: Several topical medications can alleviate hypersensitivity, including over-the-counter capsaicin cream and lidocaine cream or patches (such as Lidoderm, ZTlido, etc.).
Occupational or Physical Therapy: Adjusting daily activities or engaging in gentle, guided exercises for the affected limbs can help reduce pain, improve strength, and increase range of motion. Exercises tend to be more effective when the condition is diagnosed early.
Mirror Therapy: This therapy uses a mirror to trick the brain. By moving the healthy limb in front of a mirror or mirror box, the brain is deceived into thinking it is the CRPS-affected limb. Research suggests that this treatment can reduce pain and improve function for CRPS sufferers.
TENS (Transcutaneous Electrical Nerve Stimulation): Stimulating nerve endings with electrical impulses can sometimes help reduce chronic pain.
Biofeedback: Learning biofeedback techniques can help you become more aware of your body, which may aid in reducing tension and alleviating discomfort.
Spinal Cord Stimulation: This method involves inserting tiny electrodes into the spinal cord. Applying a small electrical current can help reduce pain.
Intrathecal Drug Pumps: This procedure involves injecting pain-relief medications directly into the spinal cord fluid.
Chinese Medicine: Insertion of long, thin needles into the body may stimulate muscles, connective tissues, and nerves, potentially improving blood flow and reducing discomfort.
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